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Research
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Clinical Trials
The main purpose of this study is to learn how well tumors that have specific genetic changes (mutations) respond to drugs that “target” those changes. This combination of a tumor with a mutation and a drug that aims at that mutation is called a “match.” There are two steps for participants in this study.
The overall goal of this study is to compare the effects, good and/or bad of the study drugs brentuximab vedotin and nivolumab (Bv-NIVO) against the standard therapy of chemotherapy with or without radiation for people with Hodgkin Lymphoma (HL) to find out which is better.
Treatment for Primary Mediastinal (Thymic) Large B-Cell Lymphoma (PMBCL) involves chemotherapy combined with an immunotherapy called rituximab. This combination is also known as the chemo-immunotherapy backbone. There are two types of chemo-immunotherapy backbone treatments for PMBCL: either R-CHOP or DA-EPOCH-R.
